Screening tests for chemical sensitization potential
Direct Peptide Reactivity Assay (DPRA)
Allergy is the body's immunological reaction to what it mistakenly believes is an infection by a foreign organism, e.g. parasite. When the immune system recognizes the presence of non-native proteins it initiates sequences of biological pathways and mechanisms to capture and eliminate the foreign material.
Simple chemicals, such as chloroplatinates, are too small to elicit an immune response themselves; first they must bind to and thereby modify some of the body's own proteins, causing them to appear 'foreign' to the immune system.
The Direct Peptide Reactivity Assay (DPRA) is an in chemico technique that tests chemicals for their ability to react with protein, and is used as a screening assay for sensitization potential – normally in combination with other, complementary screening assays that examine other parts of the biological pathway of sensitisation.» more